University of Basel

Neuroscience Network

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Discovery of a new mechanism involving GABA-B receptors and the protein AJAP-1 in the localization of these receptors in the brain (Bettler Lab)

Loss of presynaptic GABAB receptors in Ajap1-/- mice. Immunolabeling of AJAP1 and presynaptic GABAB1a (GB1a) protein in the hilus region of the hippocampus of Ajap1-/- and Ajap1+/+ mice. Presynaptic GABAB receptors are lost in the absence of AJAP1 protein.

Loss of presynaptic GABAB receptors in Ajap1-/- mice. Immunolabeling of AJAP1 and presynaptic GABAB1a (GB1a) protein in the hilus region of the hippocampus of Ajap1-/- and Ajap1+/+ mice. Presynaptic GABAB receptors are lost in the absence of AJAP1 protein.

The DBM congratulates the Bettler Lab for their recent paper accepted by Science Advances. The authors have uncovered a novel mechanism involving GABA-B receptors and the protein AJAP-1, which maintains the receptors' placement in the brain.

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