How a sweet treat can change memories

Brain circuits work together to update reward memories when flies re-experience a reward. Blue shows neuron connection hubs, magenta marks memory neurons, and green highlights reward-signaling dopamine cells. Credits: Warnecke et al., Current Biology (2026)

Brain circuits work together to update reward memories when flies re-experience a reward. Blue shows neuron connection hubs, magenta marks memory neurons, and green highlights reward-signaling dopamine cells. Credits: Warnecke et al., Current Biology (2026)

Memories must be flexible so animals can adapt when the world changes. FMI neuroscientists found that in fruit flies, simply tasting a sugar reward again can weaken all previous associated memories. This process may inspire new ways to safely update harmful or unwanted memories.

Memories help animals survive by guiding them on what to look for and what to avoid, such as remembering the smell of food or the warning signs of danger. But in a constantly changing world, those memories must also remain flexible. If a reward or threat no longer has the same meaning, the brain needs ways to update what it has learned without completely forgetting the past.
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