New insights challenge previous views about a muscle growth factor

Sections of multinucleated muscle fibers (green; nuclei in magenta).

Sections of multinucleated muscle fibers (green; nuclei in magenta).

The protein Myc has long been thought to support skeletal muscle growth. In recent work, the research team led by Prof. Markus Rüegg at the Biozentrum, University of Basel, provides compelling evidence that Myc in muscle fibers is dispensable for muscle growth. In fact, high Myc levels rapidly disrupt muscle fiber structure and function, challenging this long-held view. More