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Loss of presynaptic GABAB receptors in Ajap1-/- mice. Immunolabeling of AJAP1 and presynaptic GABAB1a (GB1a) protein in the hilus region of the hippocampus of Ajap1-/- and Ajap1+/+ mice. Presynaptic GABAB receptors are lost in the absence of AJAP1 protein.

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Discovery of a new mechanism involving GABA-B receptors and the protein AJAP-1 in the localization of these receptors in the brain (Bettler Lab)

The DBM congratulates the Bettler Lab for their recent paper accepted by Science Advances. The authors have uncovered a novel mechanism involving GABA-B receptors and the protein AJAP-1, which maintains the receptors' placement in the…
The Wolf Prize in Medicine acknowledges José-Alain Sahel's (left) and Botond Roska's exceptional contributions to the field of ophthalmology.

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Botond Roska and José-Alain Sahel win the Wolf Prize 2024 in the field of medicine

Botond Roska and José-Alain Sahel have been awarded the Wolf Prize in Medicine for their pioneering work on restoring vision to blind patients using optogenetic therapy.
Immunofluorescent image of the DG from Safb cKO mice stained with antibodies against GFP and NFIB and counter stained with DAPI. GFP expressing cells are Hes5::CreERT2-expressing NSC and their progeny.

/ Research

New study provides novel insight into molecular mechanisms regulating neural stem cell fate (Taylor Lab)

Adult murine brains and their neural stem cells (NSCs) from the hippocampus are thoroughly guided to either renew themselves or differentiate into neurons and astrocytes. However, unlike NSCs from the subventricular zone, they do not…
Inhibitory neurons (magenta) and their synapses (green) in the mouse neocortex.

Perfect balance: How the brain fine-tunes its sensitivity

A sensitive perception of the environment is crucial for guiding our behavior. However, an overly sensitive response of the brain’s neural circuits to stimuli can lead to neurodevelopmental disorders such as epilepsy. University of Basel…
A mathematical model reveals how interactions between neighboring contact sites of nerve cells influence learning.

The power of neighbors: Neighboring synapses shape learning and memory

Together with an Austrian researcher, Dr. Everton Agnes at the Biozentrum, University of Basel, has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their…
Clown loach by The Reptilarium is licensed under CC BY-SA 2.0

Sleep-wake rhythm: Fish change our understanding of sleep regulation

Contrary to common belief, not all vertebrates regulate their sleep-wake rhythm in the same way. Researchers led by Prof. Alex Schier at the Biozentrum, University of Basel, discovered that some fish – unlike humans – do not need orexin,…
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